Manny, Diego, and Sid embark upon another adventure after their continent is set adrift. Using an iceberg as a ship, they encounter sea creatures and battle pirates as they explore a new world.

Louis: [after Crash and Eddie fling themselves from trees onto the ground] Can I ask you guys something? How are you both so happy; doesn't it weigh on you that the world might be ending?
Crash: Can I tell him our secret?
[Eddie nods]
Crash: [to Louis] Come here, come here... we're very, very... stupid!
Louis: But still, you're not a teensy bit concerned about... I don't know, say imminent death!
Crash: [grabs Louis' nose] Beep.
Diego: I don't know whats wrong with me: I can't eat, can't sleep; I think I'm coming down with something.
Manny: [chuckles] I know what you've got: the "L" word.
Sid: Yeah, leprosy!
Manny: No, Sid, no. It's four letters, starts with "L", ends with "E".
Sid: Ah, lice!
Manny: No. Diego, my friend, is in love.
Gastornis bird chicks: When you drink water through your trunk, does it taste like boogers?
Ellie: Uh no... well... Sometimes, Now let's move!
Sid: My mother once told me that bad news is just good news in disguise.
Diego: Was this before she abandoned you?
Sid: Yes it was.
Granny: [Jumps in ocean] Thanks for drawing my bath, Sidney.
Sid: Granny, grab my paw.
Granny: No way. This is my first bath in decades.
[Oil is seen around her and fish begin to pop up dead around her]
Diego: There's your proof.
Sid: Quick! Somebody do something!
[Manny throws Sid in]
Sid: I got you, Granny.
Granny: Get off of me!
Sid: Ow, ow, ow, ow! Granny!
[Gets her back in the ice berg]
Granny: [to Manny and Diego] What are you peeping toms all looking at?
[They turn around disturbed]
Granny: A lady can't take a bath in peace? Eyballing me like a rump roast.
Diego: What's the life expectancy for a female sloth?
Manny: She'll outlive us all, you know that, right? Yeah, the spifeful ones live the longest.
Sid: If I don't make it, find me a wife, and tell her I love her!
Shira: You're pretty soft for a saber.
Diego: Excuse me? I happen to be a remorseless assassin.
Sid: Oh, Diego-poo! Hey, I made you another coral necklace. He keeps losing them. Hee-hee!
Captain Gutt: Surrender your ship or face my fury!
Sid: Or face your furry what?
Captain Gutt: Not furry, fury!
Shira: Two sloths, a mammoth and a sabertooth? You sound like the start of a bad joke.
Diego: And we, saved you, so that makes you the punchline, Kitty.
Shira: Don't, call me Kitty.
Diego: Okay, I won't, Kitty.
Granny: If they kiss I'm gonna puke!
Manny: [lost at sea] I can't believe this, you slept through that storm?
Granny: [dismissively] Aah, I slept through the comet that killed the unicorns.
Sid: Holy crab!
Sid: Mom, Dad, do you have Granny's teeth? She can't find them.
Granny: [Tries eating apple then tries to give to Sid] Hey! Can you chew this thing for me?
Sid: Ew, Guys? Where is everyone?
Diego: I'll handle this. Sid? Uh, your family was wiped out by an asteroid. Sorry.
Sid: What?
Manny: What Diego is trying to say is, they left. They only wanted to find you so you could take care of Granny.
Sid: Oh, come on, what kind of sick family would ditch their own Granny on someone? That's just crazy. That's just... That's just... my family.
Diego: At least you still have Granny. Right, buddy?
Sid: Yeah, Granny. Granny? Granny?
Ellie: Wow. For an old girl, she moves fast.
Sid: [after piloting Precious into vanquishing the pirates] Mission accomplished, Granny!
Granny: Ha, who says old ladies can't drive?
[last lines]
Ariscratle: [to Scrat, who is about to pull the plug on Scratlantis] No! Stop! Brother, rise above this base desire; be more than a rodent.
Peaches: So tell me, when exactly will I be allowed to hang out with boys?
Manny: When I'm dead. Plus three days, just to make sure I'm dead.
Diego: [to Shira, who he tries to offer water to] Easy, kitty: water... you need it.
Shira: [coldly] I don't need anything from you.
Diego: Fine, die of thirst, that'll really show me.
Shira: Wait. I'll take it.
[coldly]
Shira: Thank you.
Diego: You know, you have a way of saying "thank you" that makes it sound like drop dead.
Shira: It's a gift.
Flynn: [after the ship is sunk, Flynn flounders around in the water] They sank our battleship, what are we gonna do? We're all gonna drown!
Captain Gutt: [grabs him by the trunk] Flynn! You're a sea creature, you idiot!
Flynn: [sees this] Oh! Quite, sir.
[starts swimming]
Diego: [Roars] Yeah, you don't scare me mother nature! There's nothing you can throw at me that I can't handle.
[Hears whooping]
Diego: Huh?
[Gets hit by log being driven by sloths]
Eunice: I think we're almost there!
Milton: We'd better be! I just lost the steering!
Granny: Has anyone seen Precious? It's her feeding time.
Marshall: Mom! Granny's talking about her dead pet again.
Uncle Fungus: Hey, paws up, everybody!
Marshall: Paws down, Uncle, please! That is nasty.
Uncle Fungus: Whoo-hoo!
Eunice: Be careful, Milton, you're gonna hurt somebody!
[Diego tries to reach safety]
Eunice: Aah! Bad kitty!
Marshall: Rock!
Granny: [Diego flies into Granny] Whoo!
Diego: [When log has finally stopped] That was fun. Now, who should I eat first?
Uncle Fungus: [during a log ride] Hey, paws up, everybody!
Marshall: Woah! Paws down, uncle, *please*, that is nasty!
Eunice: [to Sid] I never thought I would see my little baby again, we've been searching everywhere for you.
Sid: You have? I knew it, I knew it! Deep down I knew I wasn't abandoned.
Marshall: Ah, that's incorrect, we totally abandoned you.
Eunice: But we always missed you.
[sharply to Milton]
Eunice: Right?
Milton: Yeah, right! Yeah, yeah, yeah... and we just knew Sid would want to see his poor dear Granny before... her time is up.
Granny: [angrily] I'll bury y'all and dance on your grave!
Sid: [Raz cuts him loose so as to make him walk the plank] What, you want me to walk into the water? I can't because I ate less than twenty minutes ago and you know the rule!
Raz: [crossly] That's a myth.
Sid: [uneasily] Oh ok, as long as it's safe.
Sid: We met some dinosaurs. It made no sense, but it sure was exciting.
Manny: [to Gutt on joining his crew] Look, as much as I'm tempted to join a monkey, the Easter Bunny and a giant bag of pudding, I'll pass. No one's gonna stop me getting back to my family.
Captain Gutt: [to Shira] You're a failure. I need warriors, and all I have are kitty cats and bunny rabbits!
Flynn: And a seal and a kangaroo!
Manny: You two were supposed to be responsible uncles!
Crash: What? I didn't see Peaches sneak off maybe 15 or 20 minutes ago.
Eddie: Or that she went with Louis to the falls.
Manny: The falls? Where the delinquents go?
Ellie: Relax, it's just where the kids hang out.
Manny: No, no, it's a gateway hangout. First it's the falls, then she's piercing her trunk, and the next thing you know, she's addicted to berries.
Ellie: [Chuckling] Manny! You are overreacting. She's not gonna be your little girl forever.
Manny: I know. That's what worries me.
Captain Gutt: [after seeing how the hyraxes tricked him] Oh, no: it's been a diversion.
Flynn: I know; I'm having a blast.
Captain Gutt: No, pinhead, they're stealing my ship!
Granny: [seeing the narwhals] Y'all got some ugly goldfish.
Flynn: [the fruit from Flynn's plate is missing] Where's my booty, has anyone seen it?
Gupta: Flynn, it's right behind you.
Flynn: [brandishing his rear in Silas' face] Where? Where's my booty? I can't see it.
Silas: Yuck, it's all I *can* see.
Ethan: [after escaping from a collapsed tunnel] Yo, that was insane! Hey Peach, loosen up; have some fun.
Peaches: Fun! You call that fun? I'm outta here.
Steffie: Come on, I mean do you really want to go back to hanging out with a weird molehog for a week than getting along with us?
Ethan: I mean, it's bad enough that your family's half possum...
Peaches: Bad enough? There's nothing bad about being part of my family. I *like* hanging by my tail and if you geniuses are normal, the species is going to end up extinct!
[leaves]
Steffie: Ah, yeah. Well, *your* species is going to be extinct first!
Dumb Mammoth: Haha, *burn*!
Ethan: We're the same species, geniuses.
Dumb Mammoth: What... double burn!
Captain Gutt: Sacrificing yourself for your daughter. How touching. And predictable.
Sid: Granny?
Diego: Granny?
Manny: Granny?
Sid: Come out, come out wherever you are!
Manny: Come on, Granny.
Sid: Here, Granny, Granny. I have prunes for you! Just the way you like them!
[Spit them out of his mouth]
Diego: Ugh.
Manny: Aw! I don't wanna see that.
Peaches: What if I never see him again? And the last thing we did was fight.
Ellie: Hey, your father is the toughest, most stubborn mammoth I've ever met. He'll come back for us. That's a promise.
Shira: [after Manny and the herd escape] Gutt, I can explain.
Captain Gutt: [seizes Shira by the throat] When this ends, I'll have a tiger skin hanging on my wall. I don't care whose. That mammoth has taken my ship, my bounty and now the loyalty of my crew! I will destroy him and everything he loves.
Sid: Somebody hail a whale?
Captain Gutt: [to Manny and his herd] Ahoy, down there! How lucky are you? You know these waters are infested with pirates! Glad we found you before they did: Captain Gutt, here to help.
[first lines]
Manny: [upon hearing an earthquake] What, what was that? Ellie, did you hear that?
Ellie: I heard it, Manny; whatever it is, it's miles away.
Manny: Peaches, you all right? Where is she, no teenager is ever up early.
Peaches: Oh, no! Ethan, I am so sorry! I - -Wow, you're even better-looking up close. Phenomenal.
Manny: Captain Gutt... really? You know, I have a little paunch too but ah, I wouldn't name myself after it.
Captain Gutt: [mocking] That's funny; you're a funny guy. But that's not how I got my name.
[brandishes claws]
Captain Gutt: *These* got me my name!
Captain Gutt: [in the middle of a duel] You know this ocean isn't big enough for the both of us!
Manny: Don't worry, you won't take up much space once I flatten you!
Manny: Just keep your eyes on the horizon!
Diego: I cant find the Horizon!
Silas: It's a huge bounty, Capitaine: four passengers ripe for the taking: One very smelly and one very plump.
Captain Gutt: In my ocean: what a terrible turn of events. I love a terrible turn of events.
Squint: [throwing blades at Manny] Hit the mammoth, win a prize!
Manny: Ellie, you have to get out here! Go! Go now! Stay alive! No matter how long it takes, I will find you!
Milton: And warn the community. She tends to wander!
Captain Gutt: [extending a "hand"] Morning, sunshine! Let me be the first to extend a hand of friendship.
Manny: That's your foot.
Raz: G'day Mate.
Manny: Just keep your eye on the horizon!
Diego: I can't find the horizon!