An antisocial maverick doctor who specializes in diagnostic medicine does whatever it takes to solve puzzling cases that come his way using his crack team of doctors and his wits.

[repeated line]
Dr. Gregory House: Everybody lies.
Dr. Wilson: Maybe it's Auto Immune...
Dr. Lisa Cuddy: Maybe it's Auto Immune...
Dr. Eric Foreman: Maybe it's Auto Immune...
Dr. Allison Cameron: Maybe it's Auto Immune...
Dr. Robert Chase: Maybe it's Auto Immune...
Dr. Lawrence Kutner: Maybe it's Auto Immune...
Thirteen: Maybe it's Auto Immune...
Dr. Chris Taub: Maybe it's Auto Immune...
Dr. Jeffrey 'Big Love' Cole: Maybe it's Auto Immune...
Dr. Gregory House: If someone says Auto Immune, you're fired!
Dr. Gregory House: The eyes can mislead, a smile can lie, but shoes always tell the truth.
Dr. Gregory House: A unicorn isn't a unicorn, it's a donkey with a plunger stuck to its face.
[to Cuddy]
Dr. Gregory House: Relax, I have just the thing to cheer you up... we're being sued!
Dr. Gregory House: Trouble in paradise. 2 o'clock.
Dr. Wilson: Wait, your 2 o'clock or my 2 o'clock?
Dr. Gregory House: Over there!
[repeated line]
Dr. Gregory House: We're missing something.
Dr. Gregory House: Even a drunk with a flair for the dramatic can tell himself he's an angel.
Dr. Gregory House: Technology is overrated.
[repeated line]
Dr. Lisa Cuddy: [to House] You need a lawyer.