A "National Geographic" film crew is taken hostage by an insane hunter, who takes them along on his quest to capture the world's largest - and deadliest - snake.

[Serone unravels a thirty-five foot snake skin]
Danny: The hell is this?
Paul Serone: Anaconda skin.
Danny: There's snakes out there this big?
Paul Serone: This skin is three or four years old, whatever shed it has grown since then.
Paul Serone: [seeing the anaconda]
Paul Serone: Buenos noches, beautiful.
Denise Kalberg: No, Mateo's probably just lost.
Warren Westridge: Oh WAKE UP!
Warren Westridge: Imagine, something this big captured alive. That's worth a lot of money, Gary.
Terri Flores: Jesus...
Paul Serone: Please people. Don't make me out a monster. I didn't eat the captain Mateo.
Paul Serone: They strike, wrap around you. Hold you tighter than your true love. And you get the privilege, of hearing your bones break before the power of embrace causes your veins to explode.
Warren Westridge: Asshole in one.
Gary: Is it just me or does the jungle make you really, really horny?
Paul Serone: Never look in the eyes, of those you kill. They will haunt you forever. I know.
Gary: You don't know shit about the shit we're in out here!
Denise Kalberg: How dare you! It was you, who brought that snake? You brought the devil!
Paul Serone: There's a devil inside everyone.
Terri Flores: Snakes don't eat people.
Paul Serone: Oh, they don't?
[pointing to scar down face and neck]
Paul Serone: Still no Mateo.
Danny: Hurry up! I think I can blow him up!
Terri Flores: This film was supposed to be my big break. But it turned out to be a big disaster.
[investigating a wrecked boat]
Danny: Kinda spooky in here.
Paul Serone: Think so?
Gary: There's something down there.
Paul Serone: That right.
Gary: No, I really mean it.
Paul Serone: I really mean it too.
Paul Serone: Westridge! Take my gear up to the pilot house.
Warren Westridge: I'm not your bloody poodle!
Paul Serone: What are you saying?
Warren Westridge: How dare you presume to order me about?
Paul Serone: Presume? How you like I presume to throw you in the river? You like that presume? Huh? Take it upstairs.
Warren Westridge: Thank you.
Paul Serone: This river can kill you in a thousand ways.
Paul Serone: [holds up some white dust]
Paul Serone: See this? Human bones. That's how it comes out. Ashes to ashes.
Warren Westridge: Where do you think he's gone? A walk in the woods?
Warren Westridge: I rather hoped I done my bit.
Warren Westridge: Last time I was in water like this, I was up all night picking leeches off my scrotum.
Danny: That's it, man. I'm getting the hell back to L.A...