I think the biggest problem working with me would be that I'm an only child, and so I have an internal dialogue that goes on that I just assume you can hear.
My biggest problem in live games is that I love the game so much and I don't think I ever met a poker player I didn't fundamentally like - even if they're screaming and they're acting like real jerks.
The biggest public health challenge is rebuilding health systems. In other words, if you look at cholera or maternal mortality or tuberculosis in Haiti, they're major problems in Haiti, but the biggest problem is rebuilding systems.
The single biggest problem in communication is the illusion that it has taken place.
The biggest problem with every art is by the use of appearance to create a loftier reality.
Now they show you how detergents take out bloodstains, a pretty violent image there. I think if you've got a T-shirt with a bloodstain all over it, maybe laundry isn't your biggest problem. Maybe you should get rid of the body before you do the wash.
My biggest problem in middle school was catty girls, cliques, and trying to figure out if I wanted to be a part of one of those, just figuring out who I was and all that.
My biggest problem will be lack of match toughness but I am a positive, optimistic person.
The biggest problem with dyslexic kids is not the perceptual problem, it is their perception of themselves. That was my biggest problem.
The biggest problem that we have is that California is being run now by special interests. All of the politicians are not anymore making the moves for the people, but for special interests and we have to stop that.