Moronic best friends get themselves locked inside the Bio-Dome, a science experiment, along with a group of environmental scientists for one year.

Monique: Russell, there's beer cans in the trash in the kitchen. There's beer cans in the trash in the bathroom. There's beer cans in the trash in the basement. What does that say?
Russell: We're out of beer?
Mimi: Where'd you come from?
Doyle: My mom and the authorities are still trying to figure that out.
Doyle: First Frisky now this! All I know is someone's goin' down!
Bud: Whoa Doyle! Put the gun down, put the gun down stubs! We don't need evil right now, evil is not good!
Bud: Alright people, stay with the group and remember here at the bio we're dependent on keeping homos balanced within the system!
Bud: Free Mahi Mahi! Free Mahi Mahi!
Doyle: Hi, I'm Doyle.
Bud: And I'm Bud.
Bud, Doyle: And when where not saving the environment, we're thinkin' of you, naked, thigh deep in tofu.
Bud: Shaved-down pool nazis oiling up our women and swimming with them in an olympic-sized toilet.
Olivia Biggs: Noah, it's been a nonstop moronathon!
Doyle: I've never quit anything in my life except for Chinese calligraphy, my thesis: "Tuna and You - The Early Years", Kangaroo Anatomy, Toe Photography, booger sculpture and masturbation. Well, maybe not masturbation but give me a break it's the only thing I'm good at.
Bud: 'Scuse me miss. Are you tired?
Mimi: What?
Bud: Are you tired?
Mimi: No. Why?
Bud: 'Cause you've been running through my mind all day.
Monique: [yelling] Mom! Can you please tell your love slave that if he's not part of the solution, he's part of the problem.
Russell: The only problem I have is that I've run out of Depends.
Monique: You know, Russell, there is a bathroom right around the corner.
Russell: I can't go to the bathroom. I hurt my bladder rollerblading.
Bud: We have to show the girls that we care about the environment, too.
Doyle: Do we?
Bud: No.
Computer voice: Warning. All hell is breaking loose.
Bud: Whoa, whoa, whoa! Wait a minute! You guys aren't one of those freaky cults are you? Y'know, who dance naked and you want us to take off our clothes and feed us special punch?
Falkner: ...No...
Bud: Damn! We were so close.
Falkner: What do you guys want out of life?
Bud: To die and come back as a leotard.
Bud: Russel! How'd you get a job?
Russell: Fucking President Clinton.
Doyle: You had sex with President Clinton?
Bud: I propose that we plant these seeds and I know what your thinkin' "Illegal! Illegal!" but the value of purple sticky punch goes way beyond just tokin' it!
Bud: We have chippies, We have chippies, we got lots of stuff to eat!
Bud: I'm a Sherman tank!
Doyle: [geting out of the car to go into what he thinks is a Mall to pee] Rip Van TinkleFest!
Bud: Vazquez Lake?
Doyle: More like Vazquez crap hole.
Bud: Excuse me, miss? Did it hurt?
Mimi: Did WHAT hurt?
Bud: When you fell from heaven. Did it hurt?
Bud: Dennis Hopper Blue Velvet, Oh I'm slutty Oh I'm slutty
Mimi: By the way Doyle, I've been thinking about that yoghurt thing. Fruit at the bottom, waiting to be stirred.
Young Doyle: Leave Bud alone, mom!
Doyle's Mother: [holding Bud's head underwater] I'm teaching Bud how to hold his breath underwater.
[pulls Bud's head out]
Doyle's Mother: Much better, Bud! Now let's try for three minutes.
Jen: I don't know you.
Doyle: I'm Doyle Johnson, you've seen me naked.
Monique: What about hands across America?
Bud: I had arthritis!
Monique: Farm aide?
Doyle: I had fleas!
Monique: The Save the Whales Campaign?
Bud: Salt water makes Doyle bloat...?
Bud: And you're very, VERY good at it Stubs!
Bud: Everything?
[flash back of Bud And Doyle shaving a dog]
Doyle: I don't want to have to eat you!
Bud: I don't want you to eat me either.
Roach: Denise...
Denise: Roach, one word - RAID!
Doyle: Miss? If you were yogurt, would you be fruit at the bottom or stirred?
Young Bud: Fly Mary Poppins, Fly! Supercalafragilisticexpialidocious!
Young Doyle: Can we do it again Squirrely?