A data courier, literally carrying a data package inside his head, must deliver it before he dies from the burden or is killed by the Yakuza.

Johnny Mnemonic: Yeah, the Black Shakes. What causes it?
Spider: What causes it?
[points to various pieces of equipment throughout the room]
Spider: This causes it! This causes it! This causes it! Information overload! All the electronics around you poisoning the airwaves. Technological fucking civilization. But we still have all this shit, because we can't live without it. Let me do my work.
Johnny Mnemonic: What the fuck is going on? WHAT THE FUCK IS GOING ON? You know, all my life, I've been careful to stay in my own corner. Looking out for Number One... no complications. Now, suddenly, I'm responsible for the *entire fucking world*, and everybody and his mother is trying to kill me, IF... IF... my head doesn't blow up first.
Jane: Maybe it's not just about you any more.
Johnny Mnemonic: Listen. You listen to me. You see that city over there? THAT'S where I'm supposed to be. Not down here with the dogs, and the garbage, and the fucking last month's newspapers blowing *back* and *forth*. I've had it with them, I've had it with you, I've had it with ALL THIS - *I want ROOM SERVICE*! I want the club sandwich, I want the cold Mexican beer, I want a $10,000-a-night hooker! I want my shirts laundered... like they do... at the Imperial Hotel... in Tokyo.
Johnny Mnemonic: I can carry nearly eighty gigs of data in my head.
Johnny Mnemonic: If I fall, you don't get the head, right? If you lose the head, you're fucked!
[Johnny and Jane have just broken into the computer warehouse]
Johnny Mnemonic: [swipes a pile of circuit boards and components off the desk and says to no one in particular] I need a Sino-logic 16.
Jane: [runs around the computer warehouse finding everything he calls for]
Johnny Mnemonic: Sogo 7 Data Gloves, a GPL stealth module, one Burdine intelligent translator... Thompson iPhone.
Johnny Mnemonic: No dice?
Spider: No. But I can get it out
Johnny Mnemonic: How?
Spider: A general anesthetic, a cranial drill and a pair of forceps.
Johnny Mnemonic: I could die, right?
Spider: It's gonna kill you anyway.If I take it out, you'll probably survive but lose some fine motor skills.You might not remember anything for more than three minutes.
Spider: If you're not expected then you're not invited - SO FUCK OFF!
Jane: Man owes me fifty thou' and he's scamming my phone card.
Johnny Mnemonic: And it's still our first date.
Street Preacher: [gets back on his feet after being struck by Spider's van]
[mumbles]
Street Preacher: Jesus.
Takahashi: [after being told about the state of their late CEO]
[In Japanese]
Takahashi: Ghost in the machine.
Street Preacher: [Hooky's in the bar mopping up after a long night when the Preacher enters, quoting the Bible] They err in vision, they stumble in judgment, for all the tables are full of vomit and filthiness, so that there is no place clean.
Hooky: [Hooky considers this then grins] You should have seen it before.
Street Preacher: Jesus time.
Johnny Mnemonic: If I wanted the silicon dug out of my back brain I would have gone to Mexico City! I want a full restoration; I want it all back!
Street Preacher: Who's Jones?
Spider: He's that guy... who fucks your mother!
Jane: [Johnny successfully picks a lock to a door of an electronic store] Where did you learn to do that?
Johnny Mnemonic: Had a summer job breaking and entering.
Street Preacher: Come to Jesus!
Johnny Mnemonic: You can't shoot me.
Takahashi: Not in the head.
Johnny Mnemonic: Double cheese, anchovies?
Johnny Mnemonic: "Johnny Boy", my ass. What's the fuckin' score here?
Anna Kalmann: Takahashi! Do you know what this man is carrying in his head? He's carrying the cure to NAS.
Street Preacher: HALT SINNERS!
Hooky: [Street Preacher submerges his prosthetic hand into liquid nitrogen and then smashes it]
[looking at what is left of his shattered hand]
Hooky: [groaning] Why did you do that?
Johnny Mnemonic: Pick it up, Ralfi... How bout it, Ralfi? You said you've locked down a date for the procedure.
Ralfi: And hello to you too.
Spider: Get on the table.
Johnny Mnemonic: Why?
Spider: Don't be a bigger asshole than you have to, get on the table.
Spider: Who the fuck are you anyway?
Johnny Mnemonic: Johnny.
Spider: Johnny who?
Johnny Mnemonic: Just... Johnny?
Johnny Mnemonic: Hit me.
Street Preacher: It's Jesus time!
Johnny Mnemonic: They'll negotiate; they're corporate.
Jane: So's the Yakuza.
J-Bone: [at the base of the LoTek headquarters: Heaven] Where's Spider?
Jane: He's dead.
J-Bone: [looks over at the twisted and burning hulk that was once Spider's van]
Jane: [shakes head] No, not there. Earlier.
Girl in Hotel Room: [dressing] Where's home, Johnny?
Johnny Mnemonic: Home?
[ponders the question a moment longer]
Johnny Mnemonic: Home? Would you believe I don't even know?
Girl in Hotel Room: [dons her coat] Yes, I would.
Johnny Mnemonic: Going out?
Girl in Hotel Room: Just getting some ice.
Johnny Mnemonic: [as she is leaving the room, Johnny looks over to the ice that is still cold in the bucket] We've got...
[looks at the closing door]
Johnny Mnemonic: ice.
Johnny Mnemonic: I want room service!
Johnny Mnemonic: I want to get online... I need a computer!
[Jane looks on as Johnny's hands dance in the air]
Jane: What are you doing?
Johnny Mnemonic: Making a long distance phone call. Beijing. A hotel.