The IMF is shut down when it's implicated in the bombing of the Kremlin, causing Ethan Hunt and his new team to go rogue to clear their organization's name.

William Brandt: Your line's not long enough!
Ethan Hunt: No shit!
Benji Dunn: [explaining Ethan's gloves] Easy way to remember: blue is glue.
Ethan Hunt: And when it's red?
Benji Dunn: Dead.
William Brandt: [after getting out of a giant fan] Next time, I get to seduce the rich guy.
William Brandt: I was on a protection detail in Croatia. Shadowing the assets, husband and wife. They were never supposed to know we were there. Whole thing's routine; it was a milk run. Three days in, we caught wind that a Serbian hit squad was after our couple. But my team had it under control. We knew they were coming. But I couldn't shake this feeling that I should warn the couple somehow. I wanted to find a way to let them know. But, you know, orders are orders, so I didn't. One day, the husband decides to leave the hotel and go for a run, so I follow him and I leave two men with the wife. When I get back, my guys are unconscious and the wife is gone. Local police found her body three days later. What was left of her, anyway. That was my last day in the field. I couldn't face another life or death situation after that.
Jane Carter: So what happened to the husband?
William Brandt: I never saw him again. Until two days ago in Moscow, when the Secretary introduced me to Ethan Hunt.
Benji Dunn: Why am I Pluto? It's not even a planet anymore!
William Brandt: Well, Uranus is still available.
Benji Dunn: [sarcastically] Ha, it's funny 'cuz you said anus.
William Brandt: 22 minutes to door knock.
Ethan Hunt: The countdown is not helping.
William Brandt: I'm just saying.
Ethan Hunt: Mission accomplished!
Benji Dunn: I'd be more worried about the heat.
William Brandt: [pauses] And then there's that. What heat?
Benji Dunn: Well it's just like any other computer. If you switch the fan off it's gonna get pretty hot in there.
William Brandt: Heh. Of course.
Benji Dunn: Relatively.
William Brandt: So I'm jumping into a... an oven, essentially.
Benji Dunn: Yeah, essentially. But, uh, I catch you.
William Brandt: Great.
Benji Dunn: Ethan? Jesus, I thought you were dead.
William Brandt: We are.
Ethan Hunt: Did you jump?
William Brandt: [hovering over a giant fan] Should I not have jumped? Cause I jumped!
[repeated line]
Benji Dunn: [to Brandt] And I catch you.
IMF Secretary: The President has initiated Ghost Protocol. The entire IMF has been disavowed.
Ethan Hunt: So what happens now?
IMF Secretary: Now, I've been ordered to take you back to Washington, where the DOD will label you as a rogue extremist and hang the Kremlin bombing on you and your team. Unless, you were to escape somewhere between here and the airport, having assaulted Mr. Brandt and me.
Brandt: Sir?
IMF Secretary: You would then illegally scrounge whatever material you could from a backup supply cache that I've overlooked. The same cache where your team are waiting for further orders.
Brandt: Sir, you may want to...
IMF Secretary: You will then disappear, and this conversation never having taken place, your intentions would be unclear. But if any one of your team is caught or killed, they will be branded terrorists, out to incite global nuclear war.
[handing Ethan a USB drive]
IMF Secretary: Your mission, should you choose to accept it.
[last lines]
Recorded Voice: Good evening, Mr. Hunt. 36 hours ago, there was a breach in our military's communication network. Now, an emerging terror organization known as The Syndicate has control of our entire drone fleet. Their targets unknown. Your mission, should you choose to accept it...
Leonid Lisenker: Thank God.
Wistrom: You can thank him in person.
[shoots Leonid]
Ethan Hunt: Light the fuse.
William Brandt: We all have our secrets. Don't we, Ethan?
Ethan Hunt: The Secretary is dead. The President has invoked Ghost Protocol. We're shut down. No satellite, safe house, support, or extraction. The four of us and the contents of this car are all that remains of the IMF.
Ethan Hunt: European male. Fifties. About six-foot, 180 pounds.
[shows Brandt a drawing on his hand]
Ethan Hunt: Blue eyes. Who is he?
William Brandt: A crude drawing, but by your description, that could be Kurt Hendricks. 190 IQ. Served in Swedish Special Forces. Professor of physics, Stockholm University. Specialist in nuclear endgame theory. Asked to resign... well, because he's crazy.
Benji Dunn: Love the jet.
Ethan Hunt: Wait till you see the car.
Sabine Moreau: How good is your backup?
William Brandt: The best.
Sabine Moreau: [laughing] I've killed the best.
Benji Dunn: It's not like any mission is gonna be rougher than the last one, is it?
Benji Dunn: I have arrived at the party!
Kurt Hendricks: May there be peace on Earth.
Kurt Hendricks: How will the world finally end? It is my job to predict the unthinkable. To treat the deaths of billions as a game. After 20 years of this, I was numb. Until a new question crossed my mind. What happens after the end of the world? Every two or three million years, some natural catastrophe devastates all life on Earth. But life goes on. And what little remains is made stronger. Put simply, world destruction is an unpleasant but necessary part of evolution. What happens then, I wondered, when mankind faces the next end of the world. I looked to Hiroshima, Nagasaki... thriving cities rebuilt from the ashes, monuments to the unimaginable, dedicated to the concept of peace. It occured to me here that nuclear war might have a place in the natural order. But only if it could be controlled. Only if it touched every living soul equally.
Bogdan: [to Ethan, in Russian] Sergei, please tell me there's more to this plan!
Ethan Hunt: Failure to a terrorist is just a rehearsal for success!
Jane Carter: [Telling Ethan about agent Hanaway, who was killed by a female assassin in the course of Carter's field op] It was my op. I put him in the field. And she left him just alive enough for me to see him die.
Anatoly Sidorov: [to Ethan] Our media is no more truthful than yours, American.
Jane Carter: You mind telling me what you were doing in a Russian prison?
Ethan Hunt: You mind telling me why you broke me out?
Jane Carter: This wasn't a rescue mission?
Ethan Hunt: Let me put it this way. If the Secretary wanted me out of there, it must be pretty bad out here.
IMF Secretary: The tension between the United States and Russia hasn't been this high since the Cuban Missile Crisis.
William Brandt: More fan! More fan! More fan!
Anatoly Sidorov: [to wounded Ethan] Hospital?
Ethan Hunt: IMF's been looking for an emerging extremist, code name Cobalt. He's determined to detonate a nuclear weapon however he can. We know Moreau's worked for him before.
Jane Carter: What else does IMF know about him?
Ethan Hunt: As much as you do now.
[first lines]
Russian Prisoner: [in Russian, to Burly Russian Prisoner] Hey, how did you open your cell door?