An FBI agent takes on a plane full of deadly and venomous snakes, deliberately released to kill a witness being flown from Honolulu to Los Angeles to testify against a mob boss.

Neville Flynn: ENOUGH IS ENOUGH!
[the terrified passengers on the plane turn to Neville]
Neville Flynn: I HAVE HAD IT WITH THESE MOTHERFUCKING SNAKES ON THIS MOTHERFUCKING PLANE!
Nelville Flynn: All praises to the PlayStation.
Neville Flynn: [to Dr. Price] Well, that's good news. Snakes on crack.
Nelville Flynn: Everybody listen up! We have to put a barrier between us and the snakes!
Neville Flynn: Turn this big motherfucker left, Troy!
Neville Flynn: Everybody strap in.
[pulls out his gun]
Neville Flynn: I'm about to open some fucking windows!
Neville Flynn: [TV edit] Enough is enough! I have had it with these monkey fighting snakes on this Monday through Friday plane!
Ken: [throws snake in microwave oven] Who's your daddy now, bitch?
Troy: This shit is bananas!
Three G's: [to white fan] Hey, yo, stay black.
Neville Flynn: So, uh, you are pretty good at this game, right?
Troy: Yes, man. No problem. Well, I mean, my older brother Randy has got the high score, but I'm good. Asshole never lets me hear the end of it.
Dr. Steven Price: Make it fast. Time is tissue.
[repeated line]
Neville Flynn: Do as I say, and you live.
[last lines]
Sean Jones: Do you remember the first thing you ever told me?
Neville Flynn: What the fuck's that got to do with anything?
Sean Jones: What was the first thing you ever told me?
Neville Flynn: Do as I say and you live.
Sean Jones: Exactly. Now it's your turn. Do as I say, and you'll live.
[they start surfing]
Neville Flynn: You know all those goddamn security scenarios we ran? Well, I'm stuck in the middle of one we didn't think of.
Hank Harris: What the hell you talking about?
Neville Flynn: Eddie Kim somehow managed to fill the plane with poisonous snakes.
Hank Harris: Wait, hold on. What kind of insane plan is that? He can't possibly guarantee that the snakes are gonna get to Sean.
Neville Flynn: Yeah, well, he doesn't have to guarantee it if he brings down the whole plane down.
[alternate line for television]
Neville Flynn: Enough is enough! I have had it with these mother-fucking snakes on this mother-fucking plane!
Man Bitten on Penis: Aw, fuck! Fucking bitch! Get off my dick! Aw, fuck! Fuck.
Rick: Oh, my. I was hoping you'd be the sky-candy on this flight. You're looking especially delicious this evening.
Claire Miller: I love it when you demean me, Rick.
Rick: My pleasure.
Troy: This is your new pilot Troy speaking, and sitting next to me is my main man, my brother from another mother, the biggest pimp that I know, Superfly Agent Flynn. Ladies and gentlemen, Agent Flynn.
Emmett Bradley: Sir, have you got any experience piloting a jet aircraft?
Troy: Oh, yeah. F-15's, F-16's, A-10 Warthogs, I've flown all that shit.
Emmett Bradley: Then we're all thankful to have you, sir. What squadron were you with?
Troy: The Awesome Fighting Aces.
Troy: [to Flynn] Man, I'm telling you, them video games got their shit locked down tight.
Emmett Bradley: Sir, are you telling me that your only real flight time is at the controls of a video game?
Troy: No, see, it's - it's not a video game, all right? It's a flight simulator.
Neville Flynn: Is that PlayStation or Xbox?
Troy: PlayStation 2. Man, it's got an introduction by Chuck Yeager and everything.
Neville Flynn: Everybody listen! We have to put a barrier between us and the snakes!
Troy: Fuck Randy! Fuck Randy and his high score. That's my own brother, and I say, "Fuck him!"
Neville Flynn: Sporks?
Big Leroy: Ow! Get this fucking snake off my ass!
Neville Flynn: Hey, hey, hey, we have to figure something out.
Rick: All right. Well, I know what I gotta do. We're in a 200-foot aluminum tube and we're 30,000 feet in the air. And any one of those slimy little pieces of shit can trip a circuit or a relay or a hydraulic and this bird goes down faster than a Thai hooker. So my job is to keep LAX informed on how totally screwed we are, and then find some way to keep this mother in the sky another two hours. Figure that out.
Sean Jones: Flynn, it's too hot.
Neville Flynn: I'm from Tennessee. I hadn't noticed.
Eddie Kim: You think I didn't exhaust every other option? HE SAW ME!
Neville Flynn: I need you to stay up here.
Sean Jones: Why?
Neville Flynn: Because if you die, then all of this was for nothing.
Rick: You don't think I know it's hotter than hell in here? We also have abnormal vibrations in engines one and two. I had no choice but to throttle back.
Neville Flynn: You slowed down?
Rick: Yeah. Well, you know. It's that or option B.
Claire Miller: Which is?
Rick: I go faster and the engines seize up; We eventually plummet to a horrible death; They spend the next year identifying femurs.
Claire Miller: [to the wounded Rick] You sure you can fly this thing with one hand?
Rick: Honey, you'd be surprised at what a man can do with one hand.
Mercedes Harbont: Why don't we just take a picture?
Paul: Oh, sure, let's drop it off at Jiffy Photo when we land, Einstein.
Mercedes Harbont: Ever heard of e-mail, dick-wad?
Big Leroy: [In pain from being bitten on the butt by a snake] My ass... my ass man.
Paul: [Having just thrown a small dog to be eaten by one of the snakes, much to everyone's disapproval] You'd have done the exact same thing!
Paul: Fucking dog, fucking coach, fucking Americans!
Troy: [about Three G's] Look at the Howard Hughes of rap.
Three G's: [to Troy, about heavy set woman passenger] You like that. Baby got back, front and side-to-side. Hey, y'all two get together, y'all might have, like, two 20-lb babies or something.
Grace: Oh, Lord.
Big Leroy: [seeing Maria sucking the venom out of Tommy's wound] That's what I'm talking about.
Troy: I got bit, too.
Emmett Bradley: You try to land west to east you'll come in too fast to control.
Troy: Well I suggest you speed up clearing the rest of the runways cause my ass is coming in for a landing!
[first lines]
Daniel Hayes: [to Sean] Go, get outta here. Go!
Sean Jones: Never flown first class before.
Neville Flynn: See, things are looking up already.
Extra: [after lights go out suddenly in the plane] IT'S THE SNAKES!"
Ken: [while examining bite wound on Leroy's buttocks] All right, we have to - we have to suck out the poison.
Troy: Man, I ain't sucking nothing.
Ken: Ok, I'll do it.
Big Leroy: What? Oh, there will be no sucking. Man, Troy, get this guy away from my ass!
Mercedes Harbont: [Comforting her dog, insulting the Englishman] Don't worry, Mary Kate. His hair plugs can't hurt you.
Eddie Kim: They say the higher you aim, the farther you fall.
Hank Harris: Bring in Eddie Kim. Charge him with multiple accounts of murder and attempted murder and get that piece-of-shit attorney on the phone. Yeah, tell him to ask Kim what his preference is: gas or lethal injection?
Paul: Why exactly are there snakes on this plane?
Mercedes Harbont: [to Three G's, about her dog] My doctor says she's bipolar.
Neville Flynn: What was the first thing I ever said to you?
Neville Flynn: [to Three G's] Sit your ass down, Clarence.