When human forces discover the existence of the Vampire and Lycan clans, a war to eradicate both species commences. The vampire warrior Selene leads the battle against humankind.

[last lines]
Selene: Though the world has changed, our enemy remains the same. The Lycans will rebuild. And will hunt for her father as they did for her. But as they grow stronger, so will we. The Vampire coven will not survive this world, we will reclaim it.
Eve: I dreamt of the day we would meet. Like a silly little girl. You're as cold as one already dead.
Selene: Yesterday, I was with your father. He was only a little further away from than you are now. I went to sleep. And when I awoke the next day, I learned that, overnight, 12 years had passed. And instead of the only man I ever loved, there stood a girl with his eyes. My heart is not cold. It's broken.
Eve: [Rips out Dr. Jacob Lane's throat] It's worse if you tried to fight it. Trust me.
[Selene shoves a silver-nitrate bomb into Quint's body]
Quint: I heal instantly.
Selene: I'm counting on it.
[Quint explodes]
Dr. Jacob Lane: Your kind will never be as powerful as us. No matter how hard you fight, you won't win.
Selene: You don't know me very well.
David: Defend the second rotunda!
[first lines]
Selene: The Vampire and Lycans clan have been at war for centuries before I was born, their endless conflict hidden from the human world. I was turned by a Vampire. And given the strength to avenge my family against the Lycans. And I was good at it. Then I found Michael Corvin, a human that was neither turned by Vampire nor Lycan, but a hybrid of the two. And everything changed. Allies turned enemies, and Vampire elders I had protected for now six centuries now wanted me dead. We retaliated, killed the elders, and for a brief moment of time, we were safe. But then a new darkness arose.
Dr. Jacob Lane: Everything's worked out just as we hoped. You're the first proof of it. I'm proud of you, son. Now it's with us again, we have all the genetic material we need, ready for cloning. Enough to produce an endless supply of vaccine. Imagine. Our species immune to silver. No more hiding. Every Lycan under our command as powerful as you are. I even begun injecting myself.
Quint: I only wish Mother were here to see it.
Dr. Jacob Lane: Your mother chose to remain human. She abandoned us. Remember that.
Quint: Yes, Father.
Selene: For 12 years, I was held captive by the humans. The world I once knew has changed. Vampires and Lycans are now the hunted.
Selene: You have no reason to fear us.
Thomas: Do you think I'm foolish enough to take you at your word? No reason to fear a Death Dealer who fell in love with a Lycan, who murdered two of our elders, and who, at every turn, has betrayed her own kind.
Lane's Assistant: [Selene is holding Lane's Assistant out of a window] Please! I'm the one who let you go!
Selene: Consider us even.
[Drops Lane's assistant out of the window]
Selene: This is a new war and it's only beginning.

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